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Naive CD4 T Cell Proliferation Is Controlled by Mammalian Target of Rapamycin Regulation of GRAIL Expression

In this study, we demonstrate that the E3 ubiquitin ligase gene related to anergy in lymphocytes (GRAIL) is expressed in quiescent naive mouse and human CD4 T cells and has a functional role in inhibiting naive T cell proliferation. Following TCR engagement, CD28 costimulation results in the express...

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Библиографические подробности
Главные авторы: Lin, Jack T., Lineberry, Neil B., Kattah, Michael G., Su, Leon L., Utz, Paul J., Fathman, C. Garrison, Wu, Linda
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853371/
https://ncbi.nlm.nih.gov/pubmed/19414743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0803986
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