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Blockade of endogenous tissue kallikrein aggravates renal injury by enhancing oxidative stress and inhibiting matrix degradation

Levels of tissue kallikrein (TK) are significantly lower in the urine of patients with kidney failure, and TK expression is specifically diminished in rat kidney after recovery from ischemia-reperfusion injury. In this study, we investigated the functional consequence of blocking endogenous TK activ...

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Bibliografiske detaljer
Main Authors: Liu, Yuying, Bledsoe, Grant, Hagiwara, Makato, Yang, Zhi-Rong, Shen, Bo, Chao, Lee, Chao, Julie
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853308/
https://ncbi.nlm.nih.gov/pubmed/20089675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00518.2009
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