Anthrax LFn-PA Hybrid Antigens: Biochemistry, Immunogenicity, and Protection Against Lethal Ames Spore Challenge in Rabbits

We describe a novel hybrid anthrax toxin approach that incorporates multiple components into a single vaccine product. The key domains of protective antigen (PA) and lethal factor (LF) that may be critical for inducing protective immunity are combined into one recombinant molecule. Two LF N-terminal...

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Detalhes bibliográficos
Main Authors: Li, Qin, Peachman, Kristina K., Sower, Laurie, Leppla, Stephen H., Shivachandra, Sathish B., Matyas, Gary R., Peterson, Johnny W., Alving, Carl R., Rao, Mangala, Rao, Venigalla B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853182/
https://ncbi.nlm.nih.gov/pubmed/20390054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1875035400902010092
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