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Incorporating sequence quality data into alignment improves DNA read mapping

New DNA sequencing technologies have achieved breakthroughs in throughput, at the expense of higher error rates. The primary way of interpreting biological sequences is via alignment, but standard alignment methods assume the sequences are accurate. Here, we describe how to incorporate the per-base...

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Détails bibliographiques
Auteurs principaux: Frith, Martin C., Wan, Raymond, Horton, Paul
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853142/
https://ncbi.nlm.nih.gov/pubmed/20110255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq010
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