Covalent Peroxisome Proliferator-activated Receptor γ Adduction by Nitro-fatty Acids: SELECTIVE LIGAND ACTIVITY AND ANTI-DIABETIC SIGNALING ACTIONS

The peroxisome proliferator-activated receptor-γ (PPARγ) binds diverse ligands to transcriptionally regulate metabolism and inflammation. Activators of PPARγ include lipids and anti-hyperglycemic drugs such as thiazolidinediones (TZDs). Recently, TZDs have raised concern after being linked with incr...

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Detalhes bibliográficos
Main Authors: Schopfer, Francisco J., Cole, Marsha P., Groeger, Alison L., Chen, Chen-Shan, Khoo, Nicholas K. H., Woodcock, Steven R., Golin-Bisello, Franca, Motanya, U. Nkiru, Li, Yong, Zhang, Jifeng, Garcia-Barrio, Minerva T., Rudolph, Tanja K., Rudolph, Volker, Bonacci, Gustavo, Baker, Paul R. S., Xu, H. Eric, Batthyany, Carlos I., Chen, Y. Eugene, Hallis, Tina M., Freeman, Bruce A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852971/
https://ncbi.nlm.nih.gov/pubmed/20097754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.091512
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