Targeted Deletion of Hepatocyte ABCA1 Leads to Very Low Density Lipoprotein Triglyceride Overproduction and Low Density Lipoprotein Hypercatabolism

Loss of ABCA1 activity in Tangier disease (TD) is associated with abnormal apoB lipoprotein (Lp) metabolism in addition to the complete absence of high density lipoprotein (HDL). We used hepatocyte-specific ABCA1 knock-out (HSKO) mice to test the hypothesis that hepatic ABCA1 plays dual roles in reg...

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Hauptverfasser: Chung, Soonkyu, Timmins, Jenelle M., Duong, MyNgan, Degirolamo, Chiara, Rong, Shunxing, Sawyer, Janet K., Singaraja, Roshni R., Hayden, Michael R., Maeda, Nobuyo, Rudel, Lawrence L., Shelness, Gregory S., Parks, John S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Lipids
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852959/
https://ncbi.nlm.nih.gov/pubmed/20178985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.096933
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