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Hepatic ABCA1 deficiency is associated with delayed apolipoprotein B secretory trafficking and augmented VLDL triglyceride secretion
ATP binding cassette transporter A1 (ABCA1) is a membrane transporter that facilitates nascent HDL formation. Tangier disease subjects with complete ABCA1 deficiency have <5% of normal levels of plasma HDL, elevated triglycerides (TGs), and defective vesicular trafficking in fibroblasts and macro...
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| izdano v: | Biochim Biophys Acta Mol Cell Biol Lipids |
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| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6726374/ https://ncbi.nlm.nih.gov/pubmed/28694219 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2017.07.001 |
| Oznake: |
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