Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I

Patients with Tangier disease exhibit extremely low plasma HDL concentrations resulting from mutations in the ATP-binding cassette, sub-family A, member 1 (ABCA1) protein. ABCA1 controls the rate-limiting step in HDL particle assembly by mediating efflux of cholesterol and phospholipid from cells to...

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Detalhes bibliográficos
Main Authors: Timmins, Jenelle M., Lee, Ji-Young, Boudyguina, Elena, Kluckman, Kimberly D., Brunham, Liam R., Mulya, Anny, Gebre, Abraham K., Coutinho, Jonathan M., Colvin, Perry L., Smith, Thomas L., Hayden, Michael R., Maeda, Nobuyo, Parks, John S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1074680/
https://ncbi.nlm.nih.gov/pubmed/15841208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200523915
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