Selection of a Novel and Highly Specific Tumor Necrosis Factor α (TNFα) Antagonist: INSIGHT FROM THE CRYSTAL STRUCTURE OF THE ANTAGONIST-TNFα COMPLEX

Inhibition of tumor necrosis factor α (TNFα) is a favorable way of treating several important diseases such as rheumatoid arthritis, Crohn disease, and psoriasis. Therefore, an extensive range of TNFα inhibitory proteins, most of them based upon an antibody scaffold, has been developed and used with...

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Библиографические подробности
Главные авторы: Byla, Povilas, Andersen, Mikkel H., Holtet, Thor L., Jacobsen, Helle, Munch, Mette, Gad, Hans Henrik, Thøgersen, Hans Christian, Hartmann, Rune
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2010
Предметы:
Protein Structure and Folding
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852948/
https://ncbi.nlm.nih.gov/pubmed/20179326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.063305
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