Selection of a Novel and Highly Specific Tumor Necrosis Factor α (TNFα) Antagonist: INSIGHT FROM THE CRYSTAL STRUCTURE OF THE ANTAGONIST-TNFα COMPLEX

Inhibition of tumor necrosis factor α (TNFα) is a favorable way of treating several important diseases such as rheumatoid arthritis, Crohn disease, and psoriasis. Therefore, an extensive range of TNFα inhibitory proteins, most of them based upon an antibody scaffold, has been developed and used with...

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Autors principals: Byla, Povilas, Andersen, Mikkel H., Holtet, Thor L., Jacobsen, Helle, Munch, Mette, Gad, Hans Henrik, Thøgersen, Hans Christian, Hartmann, Rune
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852948/
https://ncbi.nlm.nih.gov/pubmed/20179326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.063305
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