The BCL-2 Protein BAK Is Required for Long-chain Ceramide Generation during Apoptosis

The BCL-2 family members BAK and BAX are required for apoptosis and trigger mitochondrial outer membrane permeabilization (MOMP). Here we identify a MOMP-independent function of BAK as a required factor for long-chain ceramide production in response to pro-apoptotic stress. UV-C irradiation of wild-...

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Detalhes bibliográficos
Main Authors: Siskind, Leah J., Mullen, Thomas D., Romero Rosales, Kimberly, Clarke, Christopher J., Hernandez-Corbacho, María José, Edinger, Aimee L., Obeid, Lina M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852918/
https://ncbi.nlm.nih.gov/pubmed/20172858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.078121
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