GAP-Independent Termination of Photoreceptor Light Response by Excess γ Subunit of the cGMP-Phosphodiesterase

We have generated a mouse with rod photoreceptors overexpressing the γ inhibitory subunit (PDE6γ) of the photoreceptor G-protein effector cGMP phosphodiesterase (PDE6). PDE6γ overexpression decreases the rate of rise of the rod response at dim intensities, indicating a reduction in the gain of trans...

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Autors principals: Tsang, Steven H., Woodruff, Michael L., Chen, Ching-Kang, Yamashita, Clyde Y., Cilluffo, Marianne C., Rao, Anjali L., Farber, Debora B., Fain, Gordon L.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2006
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852461/
https://ncbi.nlm.nih.gov/pubmed/16641226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4775-05.2006
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