Derivation of human T lymphocytes from cord blood and peripheral blood with antiviral and antileukemic specificity from a single culture as protection against infection and relapse after stem cell transplantation

Viral infections and leukemic relapse account for the majority of treatment failures in patients with B-cell acute lymphoblastic leukemia (B-ALL) receiving allogeneic hematopoietic stem cell (HSC) or cord blood (CB) transplants. Adoptive transfer of virus-specific cytotoxic T lymphocytes (CTLs) prov...

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Autores principales: Micklethwaite, Kenneth P., Savoldo, Barbara, Hanley, Patrick J., Leen, Ann M., Demmler-Harrison, Gail J., Cooper, Laurence J. N., Liu, Hao, Gee, Adrian P., Shpall, Elizabeth J., Rooney, Cliona M., Heslop, Helen E., Brenner, Malcolm K., Bollard, Catherine M., Dotti, Gianpietro
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2010
Materias:
Transplantation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852368/
https://ncbi.nlm.nih.gov/pubmed/20110422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-09-242263
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