Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes

The naive phenotype of cord blood (CB) T cells may reduce graft-versus-host disease after umbilical cord blood transplantation, but this naivety and their low absolute numbers also delays immune reconstitution, producing higher infection-related mortality that is predominantly related to CMV, adenov...

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Main Authors: Hanley, Patrick J., Cruz, Conrad Russell Young, Savoldo, Barbara, Leen, Ann M., Stanojevic, Maja, Khalil, Mariam, Decker, William, Molldrem, Jeffrey J., Liu, Hao, Gee, Adrian P., Rooney, Cliona M., Heslop, Helen E., Dotti, Gianpietro, Brenner, Malcolm K., Shpall, Elizabeth J., Bollard, Catherine M.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2009
Teme:
Transplantation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738578/
https://ncbi.nlm.nih.gov/pubmed/19443656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-03-213256
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