Lenalidomide treatment promotes CD154 expression on CLL cells and enhances production of antibodies by normal B cells through a PI3-kinase–dependent pathway

Chronic lymphocytic leukemia (CLL) involves a profound humoral immune defect and tumor-specific humoral tolerance that directly contribute to disease morbidity and mortality. CD154 gene therapy can reverse this immune defect, but attempts to do this pharmacologically have been unsuccessful. The immu...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Lapalombella, Rosa, Andritsos, Leslie, Liu, Qing, May, Sarah E., Browning, Rebekah, Pham, Lan V., Blum, Kristie A., Blum, William, Ramanunni, Asha, Raymond, Chelsey A., Smith, Lisa L., Lehman, Amy, Mo, Xiaokui, Jarjoura, David, Chen, Ching-Shih, Ford, Richard, Rader, Christoph, Muthusamy, Natarajan, Johnson, Amy J., Byrd, John C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2010
Onderwerpen:
Lymphoid Neoplasia
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852364/
https://ncbi.nlm.nih.gov/pubmed/19965642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-09-242438
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items