Principles of conduction and hydrophobic gating in K(+) channels

We present the first atomic-resolution observations of permeation and gating in a K(+) channel, based on molecular dynamics simulations of the Kv1.2 pore domain. Analysis of hundreds of simulated permeation events revealed a detailed conduction mechanism, resembling the Hodgkin–Keynes “knock-on” mod...

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Detaylı Bibliyografya
Asıl Yazarlar: Jensen, Morten Ø., Borhani, David W., Lindorff-Larsen, Kresten, Maragakis, Paul, Jogini, Vishwanath, Eastwood, Michael P., Dror, Ron O., Shaw, David E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2010
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851896/
https://ncbi.nlm.nih.gov/pubmed/20231479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911691107
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