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Principles of conduction and hydrophobic gating in K(+) channels
We present the first atomic-resolution observations of permeation and gating in a K(+) channel, based on molecular dynamics simulations of the Kv1.2 pore domain. Analysis of hundreds of simulated permeation events revealed a detailed conduction mechanism, resembling the Hodgkin–Keynes “knock-on” mod...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2851896/ https://ncbi.nlm.nih.gov/pubmed/20231479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911691107 |
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