Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine

Locus ceruleus (LC)-supplied norepinephrine (NE) suppresses neuroinflammation in the brain. To elucidate the effect of LC degeneration and subsequent NE deficiency on Alzheimer's disease pathology, we evaluated NE effects on microglial key functions. NE stimulation of mouse microglia suppressed...

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Detalhes bibliográficos
Main Authors: Heneka, Michael T., Nadrigny, Fabian, Regen, Tommy, Martinez-Hernandez, Ana, Dumitrescu-Ozimek, Lucia, Terwel, Dick, Jardanhazi-Kurutz, Daniel, Walter, Jochen, Kirchhoff, Frank, Hanisch, Uwe-Karsten, Kummer, Markus P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851853/
https://ncbi.nlm.nih.gov/pubmed/20231476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909586107
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