Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine

Locus ceruleus (LC)-supplied norepinephrine (NE) suppresses neuroinflammation in the brain. To elucidate the effect of LC degeneration and subsequent NE deficiency on Alzheimer's disease pathology, we evaluated NE effects on microglial key functions. NE stimulation of mouse microglia suppressed...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Heneka, Michael T., Nadrigny, Fabian, Regen, Tommy, Martinez-Hernandez, Ana, Dumitrescu-Ozimek, Lucia, Terwel, Dick, Jardanhazi-Kurutz, Daniel, Walter, Jochen, Kirchhoff, Frank, Hanisch, Uwe-Karsten, Kummer, Markus P.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851853/
https://ncbi.nlm.nih.gov/pubmed/20231476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909586107
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky