Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase

The phosphatidylinositol 3-kinase (PI3K) signaling pathway is deregulated in many human diseases including cancer, diabetes, obesity, and autoimmunity. PI3K consists of a p110 catalytic protein and a p85α regulatory protein, required for the stabilization and localization of p110-PI3K activity. The...

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Bibliografiske detaljer
Main Authors: Chagpar, Ryaz B., Links, Philip H., Pastor, M. Chris, Furber, Levi A., Hawrysh, Andrea D., Chamberlain, M. Dean, Anderson, Deborah H.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851819/
https://ncbi.nlm.nih.gov/pubmed/20212113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908899107
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