Requirement for deoxycytidine kinase in T and B lymphocyte development

Deoxycytidine kinase (dCK) is a rate-limiting enzyme in deoxyribonucleoside salvage, a metabolic pathway that recycles products of DNA degradation. dCK phosphorylates and therefore activates nucleoside analog prodrugs frequently used in cancer, autoimmunity, and viral infections. In contrast to its...

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Autori principali: Toy, Gerald, Austin, Wayne R., Liao, Hsiang-I, Cheng, Donghui, Singh, Arun, Campbell, Dean O., Ishikawa, Tomo-o, Lehmann, Lynn W., Satyamurthy, Nagichettiar, Phelps, Michael E., Herschman, Harvey R., Czernin, Johannes, Witte, Owen N., Radu, Caius G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851816/
https://ncbi.nlm.nih.gov/pubmed/20080663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913900107
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