Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress

Nucleotide deficiency causes replication stress (RS) and DNA damage in dividing cells. How nucleotide metabolism is regulated in vivo to prevent these deleterious effects remains unknown. In this study, we investigate a functional link between nucleotide deficiency, RS, and the nucleoside salvage pa...

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Detalhes bibliográficos
Main Authors: Austin, Wayne R., Armijo, Amanda L., Campbell, Dean O., Singh, Arun S., Hsieh, Terry, Nathanson, David, Herschman, Harvey R., Phelps, Michael E., Witte, Owen N., Czernin, Johannes, Radu, Caius G.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501349/
https://ncbi.nlm.nih.gov/pubmed/23148236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121061
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