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Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells

Niemann-Pick type C disease (NPC) is a lysosomal storage disorder causing accumulation of unesterified cholesterol in lysosomal storage organelles. Recent studies have shown that hydroxypropyl-β-cyclodextrin injections in npc1(−/−) mice are partially effective in treating this disease. Using culture...

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Detalhes bibliográficos
Main Authors: Rosenbaum, Anton I., Zhang, Guangtao, Warren, J. David, Maxfield, Frederick R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851804/
https://ncbi.nlm.nih.gov/pubmed/20212119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914309107
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