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HO(•) radicals induce an unexpected high proportion of tandem base lesions refractory to repair by DNA glycosylases

Reaction of HO(•) radicals with double-stranded calf thymus DNA produces high levels of 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo) and, to a minor extent, 8-oxo-7,8-dihydro-2′-deoxyadenosine (8-oxodAdo). Formation of the hydroxylated purine lesions is explained by addition of HO(•) to the C8 po...

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Detalhes bibliográficos
Main Authors: Bergeron, François, Auvré, Frédéric, Radicella, J. Pablo, Ravanat, Jean-Luc
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851781/
https://ncbi.nlm.nih.gov/pubmed/20212167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000193107
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