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HO(•) radicals induce an unexpected high proportion of tandem base lesions refractory to repair by DNA glycosylases
Reaction of HO(•) radicals with double-stranded calf thymus DNA produces high levels of 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo) and, to a minor extent, 8-oxo-7,8-dihydro-2′-deoxyadenosine (8-oxodAdo). Formation of the hydroxylated purine lesions is explained by addition of HO(•) to the C8 po...
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Main Authors: | , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
National Academy of Sciences
2010
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2851781/ https://ncbi.nlm.nih.gov/pubmed/20212167 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000193107 |
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