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Deciphering the folding transition state structure and denatured state properties of Nucleophosmin C-terminal domain
Nucleophosmin (NPM1), one of the most abundant nucleolar proteins, is a frequent target of oncogenic mutations in acute myeloid leukaemia (AML). Mutation-induced changes at the C-terminal domain of NPM1 (Cter-NPM1) compromise its stability and cause the aberrant translocation of NPM1 to the cytosol....
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2851762/ https://ncbi.nlm.nih.gov/pubmed/20212148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910516107 |
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