Phenotypic analysis of images of zebrafish treated with Alzheimer's γ-secretase inhibitors

BACKGROUND: Several γ-secretase inhibitors (GSI) are in clinical trials for the treatment of Alzheimer's disease (AD). This enzyme mediates the proteolytic cleavage of amyloid precursor protein (APP) to generate amyloid β protein, Aβ, the pathogenic protein in AD. The γ-secretase also cleaves N...

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Autores principales: Arslanova, Dilyara, Yang, Ting, Xu, Xiaoyin, Wong, Stephen T, Augelli-Szafran, Corinne E, Xia, Weiming
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2010
Materias:
Research article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851663/
https://ncbi.nlm.nih.gov/pubmed/20307292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-10-24
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