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Phenotypic analysis of images of zebrafish treated with Alzheimer's γ-secretase inhibitors
BACKGROUND: Several γ-secretase inhibitors (GSI) are in clinical trials for the treatment of Alzheimer's disease (AD). This enzyme mediates the proteolytic cleavage of amyloid precursor protein (APP) to generate amyloid β protein, Aβ, the pathogenic protein in AD. The γ-secretase also cleaves N...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2851663/ https://ncbi.nlm.nih.gov/pubmed/20307292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-10-24 |
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