α-Synuclein overexpression increases dopamine toxicity in BE(2)-M17 cells

BACKGROUND: Oxidative stress has been proposed to be involved in the pathogenesis of Parkinson's disease (PD). A plausible source of oxidative stress in nigral dopaminergic neurons is the redox reactions that specifically involve dopamine and produce various toxic molecules, i.e., free radicals...

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Bibliografiske detaljer
Main Authors: Bisaglia, Marco, Greggio, Elisa, Maric, Dragan, Miller, David W, Cookson, Mark R, Bubacco, Luigi
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Research article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851596/
https://ncbi.nlm.nih.gov/pubmed/20334701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-11-41
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