CD28 and c-Rel-dependent Pathways Initiate Regulatory T Cell Development

Regulatory T cell (Treg) development proceeds via a two step process in which naïve CD4(+) thymocytes are first converted into CD4(+)CD25(+)CD122(+)GITR(+)Foxp3(−) Treg progenitors followed by a second step in which IL2 converts these Treg progenitors into CD4(+)Foxp3(+) Tregs. The costimulatory mol...

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Bibliografiske detaljer
Main Authors: Vang, Kieng B., Yang, Jianying, Pagán, Antonio J., Li, Lin-Xi, Wang, Junmei, Green, Jonathan M., Beg, Amer A., Farrar, Michael A.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851483/
https://ncbi.nlm.nih.gov/pubmed/20228198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0903933
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