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Engineering a two-helix bundle protein for folding studies

The SAP domain from the Saccharomyces cerevisiae THO1 protein contains a hydrophobic core and just two α-helices. It could provide a system for studying protein folding that bridges the gap between studies on isolated helices and those on larger protein domains. We have engineered the SAP domain for...

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Autori principali: Dodson, Charlotte A., Ferguson, Neil, Rutherford, Trevor J., Johnson, Christopher M., Fersht, Alan R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851443/
https://ncbi.nlm.nih.gov/pubmed/20130106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzp080
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