Targeted activation of innate immunity for therapeutic induction of autophagy and apoptosis in melanoma cells

Inappropriate drug delivery, secondary toxicities and persistent chemo- and immuno-resistance have traditionally compromised treatment response in melanoma. Using cellular systems and genetically engineered mouse models, we show that melanoma cells retain an innate ability to recognize cytosolic dsR...

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Détails bibliographiques
Auteurs principaux: Tormo, Damià, Chęcińska, Agnieszka, Alonso-Curbelo, Direna, Pérez-Guijarro, Eva, Cañón, Estela, Riveiro-Falkenbach, Erica, Calvo, Tonantzin G., Larribere, Lionel, Megías, Diego, Mulero, Francisca, Piris, Miguel A., Dash, Rupesh, Barral, Paola M., Rodríguez-Peralto, José L, Ortiz-Romero, Pablo, Tüting, Thomas, Fisher, Paul B., Soengas, María S.
Format: Artigo
Langue:Inglês
Publié: 2009
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851205/
https://ncbi.nlm.nih.gov/pubmed/19647221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.07.004
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