Bicaudal D2, Dynein, and Kinesin-1 Associate with Nuclear Pore Complexes and Regulate Centrosome and Nuclear Positioning during Mitotic Entry

BICD2 is one of the two mammalian homologues of the Drosophila Bicaudal D, an evolutionarily conserved adaptor between microtubule motors and their cargo that was previously shown to link vesicles and mRNP complexes to the dynein motor. Here, we identified a G2-specific role for BICD2 in the relativ...

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Autors principals: Splinter, Daniël, Tanenbaum, Marvin E., Lindqvist, Arne, Jaarsma, Dick, Flotho, Annette, Yu, Ka Lou, Grigoriev, Ilya, Engelsma, Dieuwke, Haasdijk, Elize D., Keijzer, Nanda, Demmers, Jeroen, Fornerod, Maarten, Melchior, Frauke, Hoogenraad, Casper C., Medema, René H., Akhmanova, Anna
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2850381/
https://ncbi.nlm.nih.gov/pubmed/20386726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000350
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