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Disruption of TGF-β signaling prevents the generation of tumor-sensitized T-reg cells and facilitates therapeutic antitumor immunity
Regulatory T cells (T-reg) represent a major roadblock to the induction of anti-tumor immunity through vaccine approaches. TGF-β is a cytokine implicated in the generation and maintenance of T-reg cells, as well as their suppressive function. These experiments examined whether the generation of tumo...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2850273/ https://ncbi.nlm.nih.gov/pubmed/19692636 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0900560 |
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