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Human Cytochrome P450c17: Single Step Purification and Phosphorylation of Serine 258 by Protein Kinase A

Cytochrome P450c17 (P450c17) is the single microsomal enzyme that catalyzes steroid 17α-hydroxylase and 17,20 lyase activities. The ratio of lyase to hydroxylase activity of human P450c17 determines whether steroidogenesis leads to the synthesis of cortisol or sex steroids. This ratio is regulated p...

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Autors principals: Wang, Yue-Hao, Tee, Meng Kian, Miller, Walter L.
Format: Artigo
Idioma:Inglês
Publicat: The Endocrine Society 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2850244/
https://ncbi.nlm.nih.gov/pubmed/20160131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2009-1247
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