Immunoglobulins from scleroderma patients inhibit the muscarinic receptor activation in internal anal sphincter smooth muscle cells

Systemic sclerosis (SSc) IgGs affecting the M(3)-muscarinic receptor (M(3)-R) have been proposed to be responsible for the gastrointestinal (GI) dysmotility in this disease. However, the effect of SSc IgGs on smooth muscle cell (SMC) function has not been studied. We determined the effect of SSc IgG...

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Hlavní autoři: Singh, Jagmohan, Mehendiratta, Vaibhav, Del Galdo, Francesco, Jimenez, Sergio A., Cohen, Sidney, DiMarino, Anthony J., Rattan, Satish
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2009
Témata:
Hormones and Signaling
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2850093/
https://ncbi.nlm.nih.gov/pubmed/19779020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00286.2009
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