IFN-β Production by TLR4-Stimulated Innate Immune Cells Is Negatively Regulated by GSK3-β

TLR 4 stimulation of innate immune cells induces a MyD88-independent signaling pathway that leads to the production of IFN-β. In this study, we demonstrate glycogen synthase kinase 3-β (GSK3-β) plays a fundamental role in this process. Suppression of GSK3-β activity by either pharmacological inhibit...

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Auteurs principaux: Wang, Huizhi, Garcia, Carlos A., Rehani, Kunal, Cekic, Caglar, Alard, Pascale, Kinane, Denis F., Mitchell, Thomas, Martin, Michael
Format: Artigo
Langue:Inglês
Publié: 2008
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849978/
https://ncbi.nlm.nih.gov/pubmed/18981097
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