IFN-β Production by TLR4-Stimulated Innate Immune Cells Is Negatively Regulated by GSK3-β

TLR 4 stimulation of innate immune cells induces a MyD88-independent signaling pathway that leads to the production of IFN-β. In this study, we demonstrate glycogen synthase kinase 3-β (GSK3-β) plays a fundamental role in this process. Suppression of GSK3-β activity by either pharmacological inhibit...

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Main Authors: Wang, Huizhi, Garcia, Carlos A., Rehani, Kunal, Cekic, Caglar, Alard, Pascale, Kinane, Denis F., Mitchell, Thomas, Martin, Michael
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849978/
https://ncbi.nlm.nih.gov/pubmed/18981097
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