Differential roles of regulatory light chain and myosin binding protein-C phosphorylations in the modulation of cardiac force development

Phosphorylation of myosin regulatory light chain (RLC) by myosin light chain kinase (MLCK) and myosin binding protein-C (cMyBP-C) by protein kinase A (PKA) independently accelerate the kinetics of force development in ventricular myocardium. However, while MLCK treatment has been shown to increase t...

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Detalhes bibliográficos
Main Authors: Colson, Brett A, Locher, Matthew R, Bekyarova, Tanya, Patel, Jitandrakumar R, Fitzsimons, Daniel P, Irving, Thomas C, Moss, Richard L
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2010
Assuntos:
Cardiovascular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849963/
https://ncbi.nlm.nih.gov/pubmed/20123786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2009.183897
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