Loss of Etv5 Decreases Proliferation and RET Levels in Neonatal Mouse Testicular Germ Cells and Causes an Abnormal First Wave of Spermatogenesis

Mice that are ets variant gene 5 (ETV5) null (Etv5(−/−)) undergo the first wave of spermatogenesis but lose all spermatogonial stem cells (SSCs) during this time. The SSC loss in Etv5(−/−) mice begins during the neonatal period, suggesting a role for ETV5 in SSC self-renewal during this period. Here...

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Main Authors: Tyagi, Gaurav, Carnes, Kay, Morrow, Carla, Kostereva, Natalia V., Ekman, Gail C., Meling, Daryl D., Hostetler, Chris, Griswold, Michael, Murphy, Kenneth M., Hess, Rex A., Hofmann, Marie-Claude, Cooke, Paul S.
Format: Artigo
Sprog:Inglês
Udgivet: Society for the Study of Reproduction, Inc. 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849825/
https://ncbi.nlm.nih.gov/pubmed/19369650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.108.075200
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