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Spermatogonial Stem Cells Derived from Infertile W(v)/W(v) Mice Self-Renew In Vitro and Generate Progeny Following Transplantation

Loss-of-function mutation of the Kit gene causes a severe defect in spermatogenesis that results in infertility due to the inability of its cognate ligand, KIT ligand (KITL), to stimulate spermatogonial proliferation and differentiation. Although self-renewal of mouse spermatogonial stem cells (SSCs...

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Autors principals: Kubota, Hiroshi, Avarbock, Mary R., Schmidt, Jonathan A., Brinster, Ralph L.
Format: Artigo
Idioma:Inglês
Publicat: Society for the Study of Reproduction, Inc. 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849820/
https://ncbi.nlm.nih.gov/pubmed/19369648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.109.075960
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