Expression of Transgenic PPP1CC2 in the Testis of Ppp1cc-Null Mice Rescues Spermatid Viability and Spermiation but Does Not Restore Normal Sperm Tail Ultrastructure, Sperm Motility, or Fertility

Two isoforms of phosphoprotein phosphatase 1, PPP1CC1 and PPP1CC2, are translated from alternatively spliced transcripts of a single gene, Ppp1cc, and differ only at their extreme C-termini. While PPP1CC1 expression is almost ubiquitous, PPP1CC2 is largely restricted to testicular germ cells and mat...

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Bibliografiska uppgifter
Huvudupphovsmän: Soler, David C., Kadunganattil, Suraj, Ramdas, Shandilya, Myers, Kimberly, Roca, Joaquim, Slaughter, Theresa, Pilder, Stephen H., Vijayaraghavan, Srinivasan
Materialtyp: Artigo
Språk:Inglês
Publicerad: Society for the Study of Reproduction, Inc. 2009
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849817/
https://ncbi.nlm.nih.gov/pubmed/19420386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.109.076398
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