Expression of Transgenic PPP1CC2 in the Testis of Ppp1cc-Null Mice Rescues Spermatid Viability and Spermiation but Does Not Restore Normal Sperm Tail Ultrastructure, Sperm Motility, or Fertility

Two isoforms of phosphoprotein phosphatase 1, PPP1CC1 and PPP1CC2, are translated from alternatively spliced transcripts of a single gene, Ppp1cc, and differ only at their extreme C-termini. While PPP1CC1 expression is almost ubiquitous, PPP1CC2 is largely restricted to testicular germ cells and mat...

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Detalhes bibliográficos
Main Authors: Soler, David C., Kadunganattil, Suraj, Ramdas, Shandilya, Myers, Kimberly, Roca, Joaquim, Slaughter, Theresa, Pilder, Stephen H., Vijayaraghavan, Srinivasan
Formato: Artigo
Idioma:Inglês
Publicado em: Society for the Study of Reproduction, Inc. 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849817/
https://ncbi.nlm.nih.gov/pubmed/19420386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.109.076398
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