Expression of Transgenic PPP1CC2 in the Testis of Ppp1cc-Null Mice Rescues Spermatid Viability and Spermiation but Does Not Restore Normal Sperm Tail Ultrastructure, Sperm Motility, or Fertility

Two isoforms of phosphoprotein phosphatase 1, PPP1CC1 and PPP1CC2, are translated from alternatively spliced transcripts of a single gene, Ppp1cc, and differ only at their extreme C-termini. While PPP1CC1 expression is almost ubiquitous, PPP1CC2 is largely restricted to testicular germ cells and mat...

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Détails bibliographiques
Auteurs principaux: Soler, David C., Kadunganattil, Suraj, Ramdas, Shandilya, Myers, Kimberly, Roca, Joaquim, Slaughter, Theresa, Pilder, Stephen H., Vijayaraghavan, Srinivasan
Format: Artigo
Langue:Inglês
Publié: Society for the Study of Reproduction, Inc. 2009
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849817/
https://ncbi.nlm.nih.gov/pubmed/19420386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.109.076398
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