FBXW7 Targets mTOR for Degradation and Genetically Cooperates with PTEN in Tumor Suppression

The enzyme mTOR (mammalian target of rapamycin) is a major target for therapeutic intervention to treat many human diseases, including cancer, but very little is known about the processes that control levels of mTOR protein. Here we show that mTOR is targeted for ubiquitination and consequent degrad...

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Bibliographic Details
Main Authors: Mao, Jian-Hua, Kim, Il-Jin, Wu, Di, Climent, Joan, Kang, Hio Chung, DelRosario, Reyno, Balmain, Allan
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849753/
https://ncbi.nlm.nih.gov/pubmed/18787170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1162981
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