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Efficient Downregulation of Multiple mRNA Targets with a Single shRNA-Expressing Lentiviral Vector
Gene silencing based on RNA interference is widely used in fundamental research and in practical applications. However, a commonly incomplete functional suppression represents a serious drawback of this technology. We describe a series of lentiviral vectors each containing a single or multiple shRNA...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2849729/ https://ncbi.nlm.nih.gov/pubmed/20064551 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.plasmid.2009.12.003 |
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