Introduction of Virulence Markers in PB2 of Pandemic Swine-Origin Influenza Virus Does Not Result in Enhanced Virulence or Transmission

In the first 6 months of the H1N1 swine-origin influenza virus (S-OIV) pandemic, the vast majority of infections were relatively mild. It has been postulated that mutations in the viral genome could result in more virulent viruses, leading to a more severe pandemic. Mutations E627K and D701N in the...

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Main Authors: Herfst, Sander, Chutinimitkul, Salin, Ye, Jianqiang, de Wit, Emmie, Munster, Vincent J., Schrauwen, Eefje J. A., Bestebroer, Theo M., Jonges, Marcel, Meijer, Adam, Koopmans, Marion, Rimmelzwaan, Guus F., Osterhaus, Albert D. M. E., Perez, Daniel R., Fouchier, Ron A. M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849492/
https://ncbi.nlm.nih.gov/pubmed/20130063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02634-09
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