Introduction of Virulence Markers in PB2 of Pandemic Swine-Origin Influenza Virus Does Not Result in Enhanced Virulence or Transmission

In the first 6 months of the H1N1 swine-origin influenza virus (S-OIV) pandemic, the vast majority of infections were relatively mild. It has been postulated that mutations in the viral genome could result in more virulent viruses, leading to a more severe pandemic. Mutations E627K and D701N in the...

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Detalhes bibliográficos
Main Authors: Herfst, Sander, Chutinimitkul, Salin, Ye, Jianqiang, de Wit, Emmie, Munster, Vincent J., Schrauwen, Eefje J. A., Bestebroer, Theo M., Jonges, Marcel, Meijer, Adam, Koopmans, Marion, Rimmelzwaan, Guus F., Osterhaus, Albert D. M. E., Perez, Daniel R., Fouchier, Ron A. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849492/
https://ncbi.nlm.nih.gov/pubmed/20130063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02634-09
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