Testing the Efficacy and Toxicity of Adenylyl Cyclase Inhibitors against Enteric Pathogens Using In Vitro and In Vivo Models of Infection

Enterotoxigenic Escherichia coli (ETEC) produces the ADP-ribosyltransferase toxin known as heat-labile enterotoxin (LT). In addition to the toxic effect of LT resulting in increases of cyclic AMP (cAMP) and disturbance of cellular metabolic processes, this toxin promotes bacterial adherence to intes...

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Detalhes bibliográficos
Main Authors: Moen, Scott T., Blumentritt, Carla A., Slater, Terry M., Patel, Shilpa D., Tutt, Christopher B., Estrella-Jimenez, Maria E., Pawlik, Jennifer, Sower, Laurie, Popov, Vsevolod L., Schein, Catherine H., Gilbertson, Scott R., Peterson, Johnny W., Torres, Alfredo G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Host Response and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849411/
https://ncbi.nlm.nih.gov/pubmed/20123712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01114-09
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