Testing the Efficacy and Toxicity of Adenylyl Cyclase Inhibitors against Enteric Pathogens Using In Vitro and In Vivo Models of Infection

Enterotoxigenic Escherichia coli (ETEC) produces the ADP-ribosyltransferase toxin known as heat-labile enterotoxin (LT). In addition to the toxic effect of LT resulting in increases of cyclic AMP (cAMP) and disturbance of cellular metabolic processes, this toxin promotes bacterial adherence to intes...

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Main Authors: Moen, Scott T., Blumentritt, Carla A., Slater, Terry M., Patel, Shilpa D., Tutt, Christopher B., Estrella-Jimenez, Maria E., Pawlik, Jennifer, Sower, Laurie, Popov, Vsevolod L., Schein, Catherine H., Gilbertson, Scott R., Peterson, Johnny W., Torres, Alfredo G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
Fag:
Host Response and Inflammation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849411/
https://ncbi.nlm.nih.gov/pubmed/20123712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01114-09
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