Inhibition of Human Immunodeficiency Virus Type 1 by Triciribine Involves the Accessory Protein Nef

Triciribine (TCN) is a tricyclic nucleoside that inhibits human immunodeficiency virus type 1 (HIV-1) replication by a unique mechanism not involving the inhibition of enzymes directly involved in viral replication. This activity requires the phosphorylation of TCN to its 5′ monophosphate by intrace...

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Bibliographic Details
Main Authors: Ptak, Roger G., Gentry, Brian G., Hartman, Tracy L., Watson, Karen M., Osterling, M. Clayton, Buckheit, Robert W., Townsend, Leroy B., Drach, John C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849366/
https://ncbi.nlm.nih.gov/pubmed/20086149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01443-09
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